Examining the regulatory value of multi-route mammalian acute systemic toxicity studies.
نویسندگان
چکیده
Regulatory information requirements for pesticides call for submission of acute systemic toxicity data for up to three different exposure routes (oral, dermal, inhalation) for both active ingredients and formulated products. Similar multi-route testing is required in the European Union and elsewhere for industrial chemicals. To determine the value of acute toxicity testing by more than one route, oral-dermal and oral-inhalation concordances among regulatory classifications were examined for large data sets of chemicals and pesticide active ingredients. Across all sectors examined, oral acute toxicity classifications for pure active substances were more severe than those derived from dermal data in more than 98% of cases, which calls into question the value of routine dermal route testing for acute toxicity. Oral classifications were equivalent to or more severe than for the inhalation route for 83% of industrial chemicals and for 48% of pesticides examined.
منابع مشابه
Executive Summary - Report of the International Workshop on In Vitro Methods for Assessing Acute Systemic Toxicity
Toxicity testing is conducted to determine the potential human health hazards of chemicals and products. Acute systemic toxicity testing is used to properly classify and appropriately label materials with regard to their lethality potential in accordance with established regulatory requirements (49 CFR 173; 16 CFR 1500; 29 CFR 1910; 40 CFR 156). Non-lethal parameters may also be evaluated in ac...
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ورودعنوان ژورنال:
- ALTEX
دوره 28 2 شماره
صفحات -
تاریخ انتشار 2011